NeuroGenomics and Informatics Center
Researchers at Washington University School of Medicine have identified a novel 10-protein AD biomarker in cerebrospinal fluid (CSF) that is independent of β-amyloid and hyperphosphorylated tau. This proteomic biomarker could advance the diagnosis and treatment of Alzheimer’s disease (AD). These findings are published in Neuron.
In order to fully understand the biology of Alzheimer’s disease, create new predictive models and identify novel causal and druggable targets large scale unbiased omic analyses are needed. For the last three years my lab has embarked on generated the largest and most detailed proteomic atlas in brain, CSF and plasma from Alzheimer’s, Parkinson’s disease […]
Cruchaga lab paired genomics and proteomics to research factors involved in TREM2 signaling and shedding. By compiling CSF samples from more than 3000 participants, they measured sTREM2 and ran a GWAS to find variants associated with protein levels. Their findings: 1) Carriers of the p.R47H AD risk variant tended to have less sTREM2 in their […]
By using a technique called high-throughput proteomics, Cruchaga Lab researchers have identified specific proteins that may help predict which patients may need to be placed on ventilators to breathe and which are most likely to die of the COVID-19 virus. Researchers learned that the presence of certain proteins may either cause severe illness or become […]
The Alzheimer’s Disease/Parkinson’s disease (AD/PD) 2023 annual conference (https://adpd.kenes.com/) begins tomorrow and will continue through Saturday, April 1. The virtual conference provides 6 full days of scientific presentations and symposia including a mix of pre-recorded oral presentations and live discussions with presenters.The Cruchaga lab is represented by 13 of our own researchers who are presenting […]
Carlos Cruchaga, PhD, has received a 2022 Zenith Fellow Award from the Alzheimer’s Association. The annual award is given to scientists who have made significant contributions to the field of Alzheimer’s disease research and are likely to make additional, substantial contributions in the future. Funding attached to the fellowships also helps support high-risk, high-reward projects in Alzheimer’s […]
Investigators at Washington University School of Medicine in St. Louis and at the University of Texas at San Antonio have received a five-year, $9 million grant from the National Institute on Aging of the National Institutes of Health (NIH) to identify how so-called transposable elements in DNA can contribute to Alzheimer’s disease. Scientists have identified […]
The Cruchaga Lab is presenting four talks and ten posters at the Alzheimer’s Association International Conference 2022 (AAIC) in San Diego, CA. The conference will kick off on Sunday, July 31 at the Convention Center. Workshops and preconferences will start in advance on Thursday, July 28. The hefty work of the team is covering frontier […]
Dr. Cruchaga, the leader of the lab and the director of the Neurogenomics and Informatics center was installed as Barbara Burton and Reuben M. Morriss III Professor on May 24th 2022. https://medicine.wustl.edu/news/cruchaga-named-morriss-professor/