We are always looking for creative, enthusiastic, and productive people who would like to work in an exciting, highly collaborative research environment.
Open Positions
| Description |
| The Cruchaga lab (https://cruchagalab.wustl.edu/) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientist. The Cruchaga lab generates and analyzes high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the lab is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. We have pioneered in the integration of genetics with omic data to identify proteomic signatures and develop novel predictive models for Alzheimer’s, Parkinson, and Dystonia as well as to identify novel proteins and pathways implicated on disease pathogenesis. We are currently analyzing brain, CSF and blood, multi-omic data (transcriptomics, proteomics and metabolomics), from a large collection of well-characterized samples to identify novel biomarker and causal and druggable targets. We are seeking for motivated researcher with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment. The new postdoctoral fellow/s will join a large team, currently twenty members, which is led by three faculty members and three senior scientists. Dr. Cruchaga’s lab is well funded with several grants from the National Institute of Ageing, the CZI and ongoing collaboration with the pharma industry. Our current research projects include the analyses of: Plasma, CSF and Brain Proteomic and metabolomics analysis Biomarker identification through the use of machine learning approaches Multi-omics data integration with genomics, transcriptomics and methylomics data senior scientists. |
| Qualifications |
| The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer science, Data science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets. A hands-on experience with large-scale human omics (preferably related to neurodegeneration) studies is expected. He/she would have solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments. A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical. In addition, familiarity to interrogate publicly available resources will be highly beneficial. We offer competitive salaries and benefits, please refer to the Human Resources website (http://hr.wustl.edu), and Information on being a postdoc at Washington University in St. Louis can be found at http://postdoc.wustl.edu/prospective-postdocs. |
| Department Name/Job Location |
| This position is in-person only, located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references.Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
| Description |
| The Cruchaga Lab, at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NeuroGenomics and Informatics Center (NGI) generates and analyzes Whole-Genome Sequencing data and high-throughput, multi-dimensional -omic data to study neurodegeneration and diseases of the central nervous system, with an emphasis on Alzheimer disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutic targets. The Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes. Characterization of the genetic topography of Alzheimer’s disease (AD) provides a unique opportunity to understand the disease. We are looking for investigators with expertise in Whole Genome and Exome data, colocalization, Mendelian Randomization, and TWAS/Fusion approaches to lead our effort to identify new genes involved in AD etiology. Recent publications on the subject: Fernandez et al., “Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center”, Sci Data. 2024 PMID: 38997326 Cruchaga et al., “Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways”, Res Sq, 2024. PMID: 38883718 Wang et al., “Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease”, Mol Neurodegenr. 2024. PMID: 38172904 Ray et al. “The Early-Onset Alzheimer’s Disease Whole-Genome Sequencing Project: Study design and methodology”, Alzheimers Dement. 2023, PMID: 37390458 Ali et al., “Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease”, Acta Neuropathol Commun, 2023 PMID: 37101235 We have recently received several NIH R01 awards to generate and analyze large WGS datasets for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and WGS/WES analyses to lead the analyses for these projects. The new postdoc(s) will join a large team, currently 30+ members, which is led by three faculty members, and regroups four postdocs, several PhD students, and three senior scientists. |
| Qualifications |
| A successful applicant will have: A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of ‘omics’ datasets, or expect to obtain a degree in the near future Hands-on experience using PLINK, SKAT, FUSION, BWA, and/or GATK with large-scale human genomic or other omics (preferably related to neurodegeneration) studies Experient performing colocalization, Mendelian randomization Solid skills in at least one programming language (R, python, or Perl) and experience working in Linux and/or high-performance cluster environments A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches Familiarity with interrogation of publicly available resources (highly beneficial) The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand AD and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. New postdoctoral research associates will work in a collegial environment in a well-stablished, well-funded research group, currently 30+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of AD. The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand Alzheimer’s disease and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. The new faculty member will work in a collegial environment in a well-established, well-funded research group, currently 35+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of Alzheimer’s disease. |
| Department Name/Job Location |
| This position is in-person only, located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references. Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |