We are always looking for creative, enthusiastic, and productive people who would like to work in an exciting, highly collaborative research environment.
Open Positions
Research Assistant Professor for Whole-Genome Sequencing in Early Onset Alzheimer’s Disease
| Description |
| The Cruchaga Lab, member of the Neurogenomics and Informatics Center (NGI) at Washington University School of Medicine invites applications for a non-tenure-track faculty position at the rank of Research Assistant Professor to develop a project to identify novel genes and pathways in Early Onset Alzheimer’s Disease utilizing Whole Genome Sequencing (WGS). Characterization of the genetic topography of Alzheimer’s disease (AD) provides a unique opportunity to understand the disease. Genomic studies of AD have primarily focused on patients affected by the late-onset form of the disease (>65), or by the early onset AD (EOAD, <65) from families with Mendelian mutations in the APP, PSEN1 and PSEN2 genes. Mutations in these three genes only explain ~10% cases. Recently, Dr. Cruchaga in collaboration with investigators at Miami and Columbia Universities are teaming up in a large effort to generate and analyze WGS in more than 3,500 EOAD cases and more than 10,000 controls from the Alzheimer Disease Sequencing Project. We are looking for investigators with expertise in Whole Genome data, colocalization, Mendelian Randomization, and TWAS/Fusion approaches to lead this large effort. The successful candidate will join an already established team that include senior and junior scientists as well as Postdocs and PhD students that will also be involved on this project. Recent publications on the subject: Takada LT, et al. Alzheimers Res Ther. 2022. PMID: 35932032 ǀ Timsina J, et al. J Alzheimers Dis. 2022, PMID: 35871246 ǀ Cruchaga C. Med (N.Y.) 2022, PMID: 35590152 ǀ Ibanez, L. Genes (Basel). 2021. PMID: 34440421 |
| Duties and Qualifications |
| Primary Duties and Responsibilities Responsible for developing end-to-end a project dissecting the genomic etiology of AD and related phenotypes Lead, develop, and troubleshoot specific analyses Multi-task projects and keeping pace in a dynamic research environment Present research advances at a variety of internal and external seminars Lead manuscript writing Direct, coordinate and supervise laboratory personal Ability to mentor students and research staff Preferred Qualifications PhD or MD with 5 years of postdoctoral experience Prominent record of research achievements in Whole Genome, Whole Exome sequencing Demonstrated expertise in Plink, QC, IBD, PCA, R, Bash, Python, Perl, Java, SAS, SQL, Docker and omic data integration Good knowledge of association analysis PRSice, MAGENTA, Mendelian Randomization, Mantra, Colocalization, Quantitative Trait Loci and Unix/Linux Independent in literature search and keeping abreast of new scientific developments Good, communications and writing skills Demonstrable commitment to diversity, equity and inclusion Basic Qualifications The candidate must hold a PhD or MD in a relevant discipline, at least 3 years of postdoctoral experience, strong publication record in Genomics of Alzheimer’s disease, advanced bioinformatics background and experience multitasking scientific projects. The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand Alzheimer’s disease and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. The new faculty member will work in a collegial environment in a well-established, well-funded research group, currently 35+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of Alzheimer’s disease. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references. Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Research Assistant Professor to study RNA Genomics in Neurodegenerative Diseases
| Description |
| The Cruchaga Lab, member of the Neurogenomics and Informatics Center (NGI) at Washington University School of Medicine invites applications for a non-tenure-track faculty position at the rank of Research Assistant Professor to study the role of circular RNAs (circRNAs) and Transposable elements (TE) in Alzheimer’s disease (AD). CircRNAs is a new category of non-coding RNAs that result from backsplicing events and are highly expressed in the central nervous system, especially in synapses. Recently, our group identified significant associations between circRNA expression and AD diagnosis, clinical dementia and neuropathological severity. We developed the first human brain atlas of circRNAs. Based on these and other recent findings, Dr. Cruchaga has two new NIH-funded projects to identify additional circRNA and TE in large and well-characterized AD cohorts. We are looking for investigators with expertise in RNA biology, high dimensional analysis of RNA-seq data, circRNAs and TE in neuroscience to lead these analyses. The successful candidate will join an already established team that include senior and junior scientists as well as Postdocs and PhD students that will also be involved on these projects. Recent publications on the subject: Dube U, et al. Nat Neurosci. 2019. PMID: 31591557 ǀ Chen HH, et al. Acta Neuropathol. Commun. 2022, PMID: 35246267 ǀ Bellenguez C, et al. Nat Genet. 2022, PMID: 35379992 ǀ Ibanez, L. Genes (Basel). 2021. PMID: 34440421 |
| Duties and Qualifications |
| Primary Duties and Responsibilities Responsible for developing end-to-end an innovative project studying circRNAs and Transposable Elements in Alzheimer’s disease Lead, develop, and troubleshoot specific analyses Multi-task projects and keeping pace in a dynamic research environment Present research advances at a variety of internal and external seminars Lead manuscript writing Direct, coordinate and supervise laboratory personal Ability to mentor students and research staff Preferred Qualifications PhD or MD with 5 years of postdoctoral experience Prominent record of research achievements in RNA biology Demonstrated expertise in RNA-seq and genetic analysis (DESeq2, DCC, Salmon, Star, Picard, FastQC, MultiQC, RATTLE, Docker, PLINK, IBD, PCA, association analyses, R, Bash) and omic data integration Independent in literature search and keeping abreast of new scientific developments Good, communications and writing skills Demonstrable commitment to diversity, equity and inclusion Basic Qualifications The candidate must hold a PhD or MD in a relevant discipline, at least 3 years of postdoctoral experience, strong publication record in RNA biology, advanced bioinformatics background and experience multitasking scientific projects. The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand Alzheimer’s disease and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. The new faculty member will work in a collegial environment in a well-established, well-funded research group, currently 35+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of Alzheimer’s disease. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references. Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Filled Positions
Programmer
| The Cruchaga lab at Washington University School of Medicine is looking for a Programmer to join our team. We are seeking applicants for a Programmer position to create and maintain relational and non-relational databases for research projects, develop websites to share scientific data and analyses, and provide support for computing in cloud / cluster environments. |
| Duties and Qualifications |
| Essential Functions: Collaborate on the design of SQL and NoSQL databases. Write and optimize SQL queries and reports Migrate and consolidate data from other systems Develop data acquisition processes from technical instruments Develop, deploy and maintain Web applications (Using R shiny or Python Web frameworks Django, TurboGears or web2py) Creating Docker containers Develop processing pipelines for cluster environments Critical Skills: The candidate will hold a bachelor’s degree in Computer Science, IT-related degree, Statistics, Bioinformatics, Biostatistics, Mathematics or similar. The candidate should have a background in programing SQL queries, and python/R (ideally developing Web applications using R Shiny), Unix (bash scripts), working knowledge of Python (using any Web application framework) HTML, CSS and JavaScript. Ideally he/she should have experience coding in FileMakerPro and NoSQL queries and should be familiar with Agile methodologies. In addition, it would be ideal to have wxperience computing in cluster environments (Portable Batch System/ Load Sharing Facility), cloud computing (AWS), sysadmin experience (linux), and Familiarity with docker (Dockerfile authoring, detached execution) |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu) |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Bioinformatics Research Analysts – GWAS or WGS/WES
| Description |
| The NeuroGenomics and Informatics (NGI) Center lead by Dr. Carlos Cruchaga at Washington University School of Medicine is recruiting Bioinformatics Research Analysts to work on Genome-Wide Association Studies (GWAS) OR Whole Genome and Whole Exome Sequencing (WGS/WES) We are seeking self-motivated, self-driven analysts to work as a part of vibrant group in a fast-paced environment. The NGI generates and analyzes Whole-Genome and high-throughput multi-dimensional omic data to study neurodegenerative diseases of the central nervous system with emphasis on Alzheimer’s and Parkinson’s disease. The goal of our research is to use genomic and multi-omic approaches to understand the biology of Alzheimer’s and Parkinson diseases. Our labs have pioneered the use of new biomarkers as endophenotypes for genetic studies. |
| Duties and Qualifications |
| Duties Develop computer programs to meet the needs of data collection, quality control, analysis and report generationPerform data analysis and writes reportsCollaborate within cross-functional teamsProvide analytical support for internal projectsMaintain database structure: includes updating, validating, curating and harmonizing longitudinal, cross-sectional data from different sourcesProvide a centralized, confidential and secure access to phenotypic data to Principal investigators, staff and usersRespond to data queries from Principal Investigators, staff and external collaboratorsQualifications Master degree in Neurogenetics, Bioinformatics, Computational Biology, Statistical Genetics, Biostatistics, Medical Statistics, Neuroscience, Genetics, Statistics, Mathematics or related Experience working in genomics with large datasets, preferably in a research environment Proficient in PLINK, QC, IBD, PCA; R, bash and excel (Python, Perl, SAS, SQL, Docker are a plus) or other analyses toolsetWorking knowledge of association analyses, PRSice, MAGENTA, Mendelian Randomization, MANTRA, Coloc, QTL and Unix/LinuxExcellent communication and problem solving skillsFamiliar working in cross-functional teamsGood understanding of computational biology and flexibility to work within a large dynamic scientific team |
| Department Name/Job Location |
| This position is located in the Cruchaga lab at the Department of Psychiatry, Washington University St. Louis.Benefits This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/. |
| Applicant Special Instructions |
| Interested candidates send cover letter and CV to Christi Gleason, MS, MBA, Program Manager (cgleason@wustl.edu ) |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Bioinformaticist for Genome Wide Association Studies
| The NeuroGenomics and Informatics (NGI) Center lead by Dr. Carlos Cruchaga at Washington University School of Medicine is recruiting a Bioinformaticist to work on Genome-Wide Association Studies. We are seeking an experienced, self-motivated, self-driven scientist to work as a part of vibrant group in a fast-paced environment. The NGI generates and analyzes Whole-Genome and high-throughput multi-dimensional omic data to study neurodegenerative diseases of the central nervous system with emphasis on Alzheimer’s and Parkinson’s disease. The goal of our research is to use genomic and multi-omic approaches to understand the biology of Alzheimer’s and Parkinson diseases. Our labs have pioneered the use of new biomarkers as endophenotypes for genetic studies.cluster environments. |
| Duties and Qualifications |
| Essential Functions: Independently develop a wide variety of computer programs to meet the needs of data collection, quality control, analysis and report generation Perform complex data analysis and writes interpretative reports Collaborate within cross-functional teams Provide analytical support for internal projects and external collaborations Improve and supervise database structure: includes updating, validating, curating and harmonizing longitudinal, cross-sectional data from different sources Provide a centralized, confidential and secure access to phenotypic data to Principal investigators Respond to data queries from Principal Investigators and external collaborators Qualifications Ph.D. degree in Neurogenetics, Bioinformatics, Computational Biology, Statistical Genetics, Biostatistics, Medical Statistics, Neuroscience, Genetics, Statistics, Mathematics or related. At least two years of experience working in genomics with large datasets, preferably in a research environment Strong background in PLINK, QC, IBD, PCA; R, bash and excel (Python, Perl, SAS, SQL, Docker are a plus) or other analyses toolset. Knowledge of association analyses, PRSice, MAGENTA, Mendelian Randomization, MANTRA, Coloc, QTL and Unix/Linux Excellent communication and problem solving skills Familiar working in cross-functional teams Good understanding of computational biology and flexibility to work within a large dynamic scientific team |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Interested candidates should send their cover letter and CV to Dr. Cruchaga (cruchagac@wustl.edu) |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Postdoctural Positions in Alzheimer’s Disease- Multi-Omics
| Description |
| The Cruchaga lab at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput, multi-dimensional -omic data to study neurodegeneration and diseases of the central nervous system, with an emphasis on Alzheimer disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutic targets. The Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes. We have pioneered the use of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data in familial (Cruchaga et al., Nature 2013., Fernandez et al., Eur J HumGenet 2016, Fernandez et al., PLoS Genetics 2017, Fernandez et al., Front Neuroscience 2018) and sporadic (Jin et al., Alzheimer Res Ther 2012, Benitez et al., PLoS Genetics, 2013, Benitez et al., N Engl J Med 2013 Jin SC Human Mol Genet 2014) Alzheimer disease to identify novel variants and genes associated with disease risk. We have recently received several NIH R01 awards to generate and analyze large WGS and omics (transcriptomics, metabolomics, proteomics) datasets for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and multi-omics analyses to lead the analyses for these projects. The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand Alzheimer’s disease and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. The new faculty member will work in a collegial environment in a well-established, well-funded research group, currently 35+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of Alzheimer’s disease. |
| Duties and Qualifications |
| A successful applicant will have: A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of ‘omics’ datasets, or expect to obtain a degree in the near future. Hands-on experience using PLINK, SKAT, BWA, and/or GATK with large-scale human genomic or other omics (preferably related to neurodegeneration) studies. Experience with Colocalization, TWAS/FUSION and Mendelian randomization appoaches Solid skills in at least one programming language (R, python, or perl) and experience working in Linux and/or high-performance cluster environments A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches Familiarity with interrogation of publicly available resources |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references. Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Postdoctural Positions in Functional Genomics
| Description |
| The Cruchaga Lab, member of the NeuroGenomics and Informatics Center, is recruiting a motivated, creative, self-driven Postdoctoral Research Associate work on patient and isogenic control induced pluripotent stem cell (iPSC)-derived neurons and downstream applications such as transcriptomics to study pathogenicity in Alzheimer disease (AD). The Postdoctoral Research Associate will be mentored by Drs. Cruchaga and Tayebi and will focus on the identification and characterization of novel genes implicated in AD. Towards this end, various cell lines combined with molecular, cellular, biochemical and pharmacological methods will be utilized to functionally characterize AD-associated genes for subsequent transcriptomic and proteomic analyses. The new Postdoctoral Research Associate will work in a collegial environment and join a multidisciplinary, diverse team in a well-stablished, well-funded research group, currently 35+ dynamic members, developing bioinformatics, analyzing multi omics data and performing functional genomics analyses to explore the frontiers of AD. |
| Duties and Qualifications |
| · Preparing and maintaining iPSC cultures. · Organizing, and performing iPSC- differentiation to neuronal and microglia cell lines. · Working closely with the senior scientist in the wet lab on the design, conduct and reporting of research projects. · Performing other wet lab experiments including DNA/RNA extraction, immunocytochemistry, ELISA, and flow cytometry. · Conducting literature reviews related to research projects, designing and performing the experiments, interpreting the results, writing reports and papers. Required Qualifications • PhD (or expect to obtain a degree in the near future) in cellular biology, molecular biology, biochemistry, genetics, neurobiology, neuroscience, or a related discipline. • Strong background and demonstrated experience in one or more of the following areas: cell biology, molecular biology, biochemistry, genetics or RNA biology. • Hands-on experience in mammalian cell culture, Northern and Western blotting, ELISA, qPCR, RNA/DNA delivery (e.g. mRNA, siRNA, ASO, lentivirus technology, transient transfection, loss/gain of function experiments), immunocytochemistry, light and confocal microscopy. Prior experience with induced pluripotent stem cell (iPSC) cultures is advantageous. • Knowledge of flow cytometry, cell sorting, high-throughput screening and cell-based screening (e.g., luciferase assays, high-content imaging, massively parallel/multiplexed assays, etc.) is desirable but not required. • Ability to interpret and discuss experiments, critically contribute to writing of manuscripts and grant proposals is expected. • The candidate should be well-organized, able to multi-task with excellent lab bench skills. Must be able to work independently and as part of a team. • Prior experience in AD or neurodegenerative diseases research is desirable but not required. • Proficiency in written and oral English is mandatory. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) Please send the materials in one single PDF to the attention of Dr. Tayebi (ntayebi@wustl.edu) |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Postdoctoral Research Associate – Bioinformatics of circular RNAs in Alzheimer’s Disease
| Description |
| The Cruchaga Lab, member of the Neurogenomics and Informatics Center (NGI) at Washington University School of Medicine invites applications for a non-tenure-track faculty position at the rank of Research Assistant Professor to study the role of circular RNAs (circRNAs) and Transposable elements (TE) in Alzheimer’s disease (AD). CircRNAs is a new category of non-coding RNAs that result from backsplicing events and are highly expressed in the central nervous system, especially in synapses. Recently, our group identified significant associations between circRNA expression and AD diagnosis, clinical dementia and neuropathological severity. We developed the first human brain atlas of circRNAs. Based on these and other recent findings, Dr. Cruchaga has two new NIH-funded projects to identify additional circRNA and TE in large and well-characterized AD cohorts. We are looking for investigators with expertise in RNA biology, high dimensional analysis of RNA-seq data, circRNAs and TE in neuroscience to lead these analyses. The successful candidate will join an already established team that include senior and junior scientists as well as Postdocs and PhD students that will also be involved on these projects. Recent publications on the subject: Dube U, et al. Nat Neurosci. 2019. PMID: 31591557 ǀ Chen HH, et al. Acta Neuropathol. Commun. 2022, PMID: 35246267 ǀ Bellenguez C, et al. Nat Genet. 2022, PMID: 35379992 ǀ Ibanez, L. Genes (Basel). 2021. PMID: 34440421 |
| Duties and Qualifications |
| Primary Duties and Responsibilities Responsible for developing end-to-end an innovative project studying circRNAs and Transposable Elements in Alzheimer’s disease Lead, develop, and troubleshoot specific analyses Multi-task projects and keeping pace in a dynamic research environment Present research advances at a variety of internal and external seminars Lead manuscript writing Direct, coordinate and supervise laboratory personal Ability to mentor students and research staff Preferred Qualifications PhD or MD with 5 years of postdoctoral experience Prominent record of research achievements in RNA biology Demonstrated expertise in RNA-seq and genetic analysis (DESeq2, DCC, Salmon, Star, Picard, FastQC, MultiQC, RATTLE, Docker, PLINK, IBD, PCA, association analyses, R, Bash) and omic data integration Independent in literature search and keeping abreast of new scientific developments Good, communications and writing skills Demonstrable commitment to diversity, equity and inclusion Basic Qualifications The candidate must hold a PhD or MD in a relevant discipline, at least 3 years of postdoctoral experience, strong publication record in RNA biology, advanced bioinformatics background and experience multitasking scientific projects. The Cruchaga Lab provides a unique collaborative scientific environment emphasizing the analysis of functional genomics and high dimensional omics data to understand Alzheimer’s disease and other dementias. The Lab is member of the NGI that includes faculties with expertise in genetics, genomics, multi-omics, machine learning, iPSC, animal models of neurodegenerative diseases and Clinical research. The new faculty member will work in a collegial environment in a well-established, well-funded research group, currently 35+ dynamic members, developing bioinformatics tools and analyzing multi omics data to explore the frontiers of Alzheimer’s disease. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Applicants should submit: 1) cover letter describing their interest in the position, 2) curriculum vitae, 3) one-page description of their single-most important paper highlighting the novelty of the findings (accepted papers only) and 4) names and contact information of 3 professional references. Please send the materials in one single PDF to the attention of the Search Committee at cgleason@wustl.edu. |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Postdoctoral Research Scientist WUSTL – GSK
| Description |
| The Cruchaga lab in collaboration with the GSK Genetics Therapy Area is recruiting a self-motivated, self-driven Postdoctoral Research Scientist to work on QTL mapping, Colocalization and Mendelian Randomization. Our group generates and analyzes genetic and multi-tissue proteomic data from large and well characterized cohorts of Alzheimer disease cases and controls. |
| Job Description |
| Perform daily tasks to ensure the smooth functioning of the NGI Center administrative office, including: Run the administrative reception desk: answer phones, greet, direct visitors, ensure confidentiality, and maintain a professional atmosphere of the center at all times. Sort incoming mail and serve as liaison with mail services. Schedule and maintain calendar and mailing list for the NGI Center. Schedule, send, and receive communication to/from the NGI about lectures, talks, meetings, conferences and symposiums. Manage and stock office supplies; coordinate purchase of supplies as needed. Monitor the general maintenance of the center, notify Facilities Department of problems, place work orders, and follow-up with housekeeping on the completion of tasks. Serve as point of contact for internal and external administrative related matters. Maintain all center keys, locks and mailboxes. Coordinate ordering and distribution of supplies and handle problems concerning material received. Coordinate administrative meeting and maintain agenda and minutes. Help maintain and establish lab and center policies, procedures and objectives including regulatory records, reports, and notifications as necessary. Perform other duties as assigned. Preferred Qualifications Bachelor’s degree. At least five years in an administrative position. Experience posting data/information on the internet via social networks (Twitter) and basic website design (WordPress). Experience with Workday. Excellent interpersonal skills to work with faculty, staff, and students. Experience in a scientific laboratory or clinic. Knowledge of grants administration. Desire to work in environment of growth and change. Commitment to exceptional service and responsiveness. Discrete and ability to maintain strict confidentiality. Ability to work both independently and in collaborative groups. Knowledge of bookkeeping and finance. Ability to balance and manage several projects and tasks at one time in a high-activity setting and prioritize projects. Required Qualifications High school diploma or equivalent high school certification. Three years of relevant experience. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Interested candidates please apply at Washington University Jobs Website |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Postdoctoral Research Associate Functional Genomics of circular RNAs in Alzheimer’s Disease
| Description |
| The Cruchaga Lab, member of the NeuroGenomics and Informatics Center, is recruiting a motivated, creative, self-driven Postdoctoral Research Associate to functionally characterize the role of circular RNAs (circRNAs) in Alzheimer’s disease (AD). CircRNA is a new category of non-coding RNAs that result from backsplicing events and are highly expressed in the central nervous system, especially in synapses. Recently, our group identified significant associations between circRNA expression and AD diagnosis, clinical dementia and neuropathological severity. The Postdoctoral Research Associate will be mentored by Drs. Carlos Cruchaga and Niko Nykänen and will focus on the identification and modification of circRNAs in in vitro models of Neurodegenerative Diseases. Towards this end, various cell lines combined with molecular, cellular, biochemical and pharmacological methods will be utilized to functionally characterize AD-associated circRNAs for subsequent transcriptomic and proteomic analyses. The new Postdoctoral Research Associate will work in a collegial environment and join a multidisciplinary, diverse team in a well-stablished, well-funded research group, currently 30+ dynamic members, developing bioinformatics, analyzing multi omics data and performing functional genomics analyses to explore the frontiers of AD. Recent publications on the subject: Dube U, et al. Nat Neurosci. 2019. PMID: 31591557 ǀ Chen HH, et al. Acta Neuropathol. Commun. 2022, PMID: 35246267 ǀ Bellenguez C, et al. Nat Genet. 2022, PMID: 35379992 ǀ Ibanez, L. Genes (Basel). 2021. PMID: 34440421 |
| Required Qualifications |
| PhD (or expect to obtain a degree in the near future) in cellular biology, molecular biology, biochemistry, genetics, neurobiology, neuroscience, or a related discipline. Strong background and demonstrated experience in one or more of the following areas: cell biology, molecular biology, biochemistry, genetics or RNA biology. Hands-on experience in mammalian cell culture, Northern and Western blotting, ELISA, qPCR, RNA/DNA delivery (e.g. mRNA, siRNA, ASO, lentivirus technology, transient transfection, loss/gain of function experiments), immunocytochemistry, light and confocal microscopy. Prior experience with induced pluripotent stem cell (iPSC) cultures is advantageous. Knowledge of flow cytometry, cell sorting, high-throughput screening and cell-based screening (e.g., luciferase assays, high-content imaging, massively parallel/multiplexed assays, etc.) is desirable but not required. Ability to interpret and discuss experiments, critically contribute to writing of manuscripts and grant proposals is expected. The candidate should be well-organized, able to multi-task with excellent lab bench skills. Must be able to work independently and as part of a team. Prior experience in AD or neurodegenerative diseases research is desirable but not required. Proficiency in written and oral English is mandatory. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Interested candidates should send Cover Letter and CV to Christi Gleason, Program Manager cgleason@wustl.edu |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Program Manager
| Description |
The Cruchaga lab is a multidisciplinary team working at the forefront of personalized medicine. The goal of the lab is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches. We are looking for an experienced project manager to work directly with the center director. The project manager will be responsible for the oversight and administration of multiple research projects progress report and manuscript writing, and publication, coordination of the activities of a multidisciplinary team. The Program Manager will be responsible for coordination of program activities, including national consortia projects and local projects. The Program Manager will also be responsible for content development for grants, manuscripts, and program web pages. |
| Duties and Qualifications |
Holds responsibility for day-to-day activities of the Cruchaga lab.Assists with drafting, writing, editing, and galley-proofing of progress report abstracts and article for publication.Composes annual report for the lab, maintains content for the center website and social media.Supervises support staff and advises senior faculty in personnel management or internal policy.May prepare and maintain minutes from meetings, formal voting procedures, and committee activity related to proposals, ensuring follow up on decisions made.Provides planning and coordination of meetings and schedules various events and/or training. Establishes/enhances various contacts’, and contact with other centers and research groups to facilitate collaboration and exchange of information. Participates in project review meetings and report preparation and analysis.Provides budgetary management to the program. Preferred QualificationsPhD degree in genetics, biology, or neuroscience or related subject with five years of related experience, or equivalent combination of education and experience totaling nine years.Excellent administrative skills.Experience with research.Significant experience with word processing, spreadsheets, graphics, database and internet.Excellent oral and written communication skills.Able to work independently and manage multiple assignments with various levels of priority.Attention to detail and accuracy are essential. Required Qualifications Bachelor’s degree and five years of related experience or a master’s degree and three years of related experience |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
Interested candidates should send their cover letter and CV to Dr. Carlos Cruchaga (cruchagac@wustl.edu ) |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |
Assistant to the Director/Administrative Coordinator
| Description |
| The Neurogenomics and Informatics Center (NGI) Center is a multidisciplinary team working at the forefront of personalized medicine. Investigators at the NGI use state of the art techniques to understand the biology of neurodegenerative diseases (Alzheimer and related dementias) to identify novel therapeutic targets. This position coordinates office functions, programs and schedules, provides administrative services, and performs specialized/technical duties with minimum supervision. |
| Job Description |
| Primary Duties and Responsibilities Perform daily tasks to ensure the smooth functioning of the NGI Center administrative office, including: Run the administrative reception desk: answer phones, greet, direct visitors, ensure confidentiality, and maintain a professional atmosphere of the center at all times. Sort incoming mail and serve as liaison with mail services. Schedule and maintain calendar and mailing list for the NGI Center. Schedule, send, and receive communication to/from the NGI about lectures, talks, meetings, conferences and symposiums. Manage and stock office supplies; coordinate purchase of supplies as needed. Monitor the general maintenance of the center, notify Facilities Department of problems, place work orders, and follow-up with housekeeping on the completion of tasks. Serve as point of contact for internal and external administrative related matters. Maintain all center keys, locks and mailboxes. Coordinate ordering and distribution of supplies and handle problems concerning material received. Coordinate administrative meeting and maintain agenda and minutes. Help maintain and establish lab and center policies, procedures and objectives including regulatory records, reports, and notifications as necessary. Perform other duties as assigned. Preferred Qualifications Bachelor’s degree. At least five years in an administrative position. Experience posting data/information on the internet via social networks (Twitter) and basic website design (WordPress). Experience with Workday. Excellent interpersonal skills to work with faculty, staff, and students. Experience in a scientific laboratory or clinic. Knowledge of grants administration. Desire to work in environment of growth and change. Commitment to exceptional service and responsiveness. Discrete and ability to maintain strict confidentiality. Ability to work both independently and in collaborative groups. Knowledge of bookkeeping and finance. Ability to balance and manage several projects and tasks at one time in a high-activity setting and prioritize projects. Required Qualifications High school diploma or equivalent high school certification. Three years of relevant experience. |
| Department Name/Job Location |
| This position is located at the NeuroGenomics and Informatics Center, Department of Psychiatry, Washington University in St. Louis. |
| Applicant Special Instructions |
| Interested candidates please apply at Washington University Jobs Website |
| EOE Statement |
| Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. |