Welcome to the Cruchaga Lab

The Cruchaga Lab is dedicated to advancing the understanding of neurodegenerative diseases such as Alzheimer disease, other dementias, and stroke, by generating, analyzing and leveraging multi-tissue multi-omic data from large and well characterized cohorts.

Flow chart of the lab's processes for Alzheimer disease molecular phenotyping to better understand AD biology; identify new genes, drug targets, and biomarkers; and generate novel prediction models for AD.
We combine multi-tissue, multi-comic data, such as WGS, proteomics, epigenetic, metabolomics, transcriptomics, and lipidomics with multiple tissues (brain, plasma, csf, and iPSCs) from genetically defined Alzheimer disease cases (sporadic AD, mendelian AD, and risk variant carriers). We use deep molecular profiling analyze the data and to identify novel risk and protective variants, generate individual-level prediction models, and identify drug targets and drugs for repositioning.

The Cruchaga Lab is part of the Neurogenomics and Informatics (NGI) Center