Welcome to the Cruchaga Lab
The Cruchaga Lab is dedicated to advancing the understanding of neurodegenerative diseases such as Alzheimer disease, other dementias, and stroke, by generating, analyzing and leveraging multi-tissue multi-omic data from large and well characterized cohorts.
The Cruchaga Lab is part of the Neurogenomics and Informatics (NGI) Center
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Novel Alzheimer’s biomarkers identified from cerebrospinal fluid
Researchers at Washington University School of Medicine have identified a novel 10-protein AD biomarker in cerebrospinal fluid (CSF) that is independent of β-amyloid and hyperphosphorylated tau. This proteomic biomarker could advance the diagnosis and treatment of Alzheimer’s disease (AD). These findings are published in Neuron.
Large scale unbiased proteomics uncovers novel pathways and biomarkers for Alzheimer’s disease
In order to fully understand the biology of Alzheimer’s disease, create new predictive models and identify novel causal and druggable targets large scale unbiased omic analyses are needed. For the last three years my lab has embarked on generated the largest and most detailed proteomic atlas in brain, CSF and plasma from Alzheimer’s, Parkinson’s disease […]
All Roads Lead to TREM2: Gearing Up to Target This Receptor
Cruchaga lab paired genomics and proteomics to research factors involved in TREM2 signaling and shedding. By compiling CSF samples from more than 3000 participants, they measured sTREM2 and ran a GWAS to find variants associated with protein levels. Their findings: 1) Carriers of the p.R47H AD risk variant tended to have less sTREM2 in their […]
COVID-19 patients’ blood plasma shows who is most likely to become severely ill
By using a technique called high-throughput proteomics, Cruchaga Lab researchers have identified specific proteins that may help predict which patients may need to be placed on ventilators to breathe and which are most likely to die of the COVID-19 virus. Researchers learned that the presence of certain proteins may either cause severe illness or become […]
Cruchaga Lab at AD/PD 2023
The Alzheimer’s Disease/Parkinson’s disease (AD/PD) 2023 annual conference (https://adpd.kenes.com/) begins tomorrow and will continue through Saturday, April 1. The virtual conference provides 6 full days of scientific presentations and symposia including a mix of pre-recorded oral presentations and live discussions with presenters.The Cruchaga lab is represented by 13 of our own researchers who are presenting […]