Cruchaga lab paired genomics and proteomics to research factors involved in TREM2 signaling and shedding. By compiling CSF samples from more than 3000 participants, they measured sTREM2 and ran a GWAS to find variants associated with protein levels. Their findings: 1) Carriers of the p.R47H AD risk variant tended to have less sTREM2 in their […]
Author: cgleason
COVID-19 patients’ blood plasma shows who is most likely to become severely ill
By using a technique called high-throughput proteomics, Cruchaga Lab researchers have identified specific proteins that may help predict which patients may need to be placed on ventilators to breathe and which are most likely to die of the COVID-19 virus. Researchers learned that the presence of certain proteins may either cause severe illness or become […]
Cruchaga Lab at AD/PD 2023
The Alzheimer’s Disease/Parkinson’s disease (AD/PD) 2023 annual conference (https://adpd.kenes.com/) begins tomorrow and will continue through Saturday, April 1. The virtual conference provides 6 full days of scientific presentations and symposia including a mix of pre-recorded oral presentations and live discussions with presenters.The Cruchaga lab is represented by 13 of our own researchers who are presenting […]
$9 million to fund study of ‘jumping genes’ in Alzheimer’s
Investigators at Washington University School of Medicine in St. Louis and at the University of Texas at San Antonio have received a five-year, $9 million grant from the National Institute on Aging of the National Institutes of Health (NIH) to identify how so-called transposable elements in DNA can contribute to Alzheimer’s disease. Scientists have identified […]