Welcome to the Cruchaga Lab

The Cruchaga Lab is dedicated to advancing the understanding of neurodegenerative diseases such as Alzheimer disease, other dementias, and stroke, by generating, analyzing and leveraging multi-tissue multi-omic data from large and well characterized cohorts.

Flow chart of the lab's processes for Alzheimer disease molecular phenotyping to better understand AD biology; identify new genes, drug targets, and biomarkers; and generate novel prediction models for AD.
We combine multi-tissue, multi-comic data, such as WGS, proteomics, epigenetic, metabolomics, transcriptomics, and lipidomics with multiple tissues (brain, plasma, csf, and iPSCs) from genetically defined Alzheimer disease cases (sporadic AD, mendelian AD, and risk variant carriers). We use deep molecular profiling analyze the data and to identify novel risk and protective variants, generate individual-level prediction models, and identify drug targets and drugs for repositioning.

The Cruchaga Lab is part of the Neurogenomics and Informatics (NGI) Center

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$9 million to fund study of ‘jumping genes’ in Alzheimer’s

Investigators at Washington University School of Medicine in St. Louis and at the University of Texas at San Antonio have received a five-year, $9 million grant from the National Institute on Aging of the National Institutes of Health (NIH) to identify how so-called transposable elements in DNA can contribute to Alzheimer’s disease. Scientists have identified […]

Cruchaga lab at AAIC 2022

The Cruchaga Lab is presenting four talks and ten posters at the Alzheimer’s Association International Conference 2022 (AAIC) in San Diego, CA. The conference will kick off on Sunday, July 31 at the Convention Center.  Workshops and preconferences will start in advance on Thursday, July 28. The hefty work of the team is covering frontier […]

Cruchaga named Morriss Professor

Dr. Cruchaga, the leader of the lab and the director of the Neurogenomics and Informatics center was installed as Barbara Burton and Reuben M. Morriss III Professor on May 24th 2022. https://medicine.wustl.edu/news/cruchaga-named-morriss-professor/

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