Large scale unbiased proteomics uncovers novel pathways and biomarkers for Alzheimer’s disease

In order to fully understand the biology of Alzheimer’s disease, create new predictive models and identify novel causal and druggable targets large scale unbiased omic analyses are needed. For the last three years my lab has embarked on generated the largest and most detailed proteomic atlas in brain, CSF and plasma from Alzheimer’s, Parkinson’s disease […]

All Roads Lead to TREM2: Gearing Up to Target This Receptor

Cruchaga lab paired genomics and proteomics to research factors involved in TREM2 signaling and shedding. By compiling CSF samples from more than 3000 participants, they measured sTREM2 and ran a GWAS to find variants associated with protein levels. Their findings: 1) Carriers of the p.R47H AD risk variant tended to have less sTREM2 in their […]

COVID-19 patients’ blood plasma shows who is most likely to become severely ill

By using a technique called high-throughput proteomics, Cruchaga Lab researchers have identified specific proteins that may help predict which patients may need to be placed on ventilators to breathe and which are most likely to die of the COVID-19 virus. Researchers learned that the presence of certain proteins may either cause severe illness or become […]